PD-L1 expression correlates with the oncological severity and prognosis of early-stage lung cancer.

ABSTRACT:

Purpose

The expression of PD-L1 is linked to lung cancer severity; however, its prognostic value after resection is unclear. In this study, we investigated its role in resected lung cancers.

Methods

We analyzed 658 patients with stage pIA-IIIA NSCLC who underwent complete resection. We assessed the PD-L1 expression by stage and its link to cancer severity, focusing further on its prognostic impact in resected stage I cell lung cancer.

Results

The high expression of PD-L1 increased with disease progression (13.0% in IA to 36.2% in III). In stage I non-small cell lung cancer, elevated PD-L1 expression levels were more common in patients with serum CEA levels ≥ 5 (26.0%), SUVmax ≥ 5 (26.7%), and squamous cell carcinoma (41.5%). PD-L1-negative patients showed a better pro

SUBMITTER: Onodera K 

PROVIDER: S-EPMC12534232 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature