Trends in Surgical Treatment for cT4 Breast Cancer After Neoadjuvant Systemic Therapy: A Nationwide Study in The Netherlands.

ABSTRACT:

Background

Current guidelines recommend neoadjuvant systemic therapy (NST) followed by modified radical mastectomy (MRM) for stage T4 breast cancer. In this study, trends in MRM and de-escalated surgery of cT4a-c and cT4d breast cancer were evaluated and the impact of treatment on survival was assessed.

Methods

Patients with cT4N_anyM0 breast cancer who received NST between 1989 to 2020 were selected from the Netherlands Cancer Registry. Rates of MRM and de-escalated breast/axillary surgery were analyzed for the periods 1989-1999, 2000-2009, and 2010-2020. Cox proportional hazard regression with inverse probability weighing was used to estimate for confounding-adjusted hazard ratios (HRs) for overall survival. Crude relative survival was calculated using excess mor

SUBMITTER: Jansen BAM 

PROVIDER: S-EPMC12534241 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature