Breast Cancer Upstaging Risk and In Vivo Tumor Growth Rates Associated with Preoperative Delays.

ABSTRACT:

Background

Preoperative delay when treating breast cancer confers poorer outcomes, but growth rates and the upstaging likelihoods per delay interval remain unknown. This study evaluated upstaging risk, nodal spread, and tumor growth rates in vivo while awaiting treatment.

Patients and methods

Registry-based data from the national cancer database was reviewed for patients treated between 2010 and 2020 at commission on cancer-accredited facilities, with nonmetastatic, noninflammatory breast cancer, undergoing surgery first.

Results

Among 1,018,219 patients, 11.5% had primary tumoral upstaging and 14.1% had nodal upstaging. For every 30 d between diagnosis and surgery, the adjusted odds ratios (ORs) for tumor upstaging was 1.11 for ductal carcinoma in situ (DCIS) (95% CI

SUBMITTER: Bleicher RJ 

PROVIDER: S-EPMC12534249 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature