Early subtypes and progressions of progressive supranuclear palsy: a data-driven brain bank study.

ABSTRACT:

Background

Progressive supranuclear palsy (PSP) is typically characterized by vertical supranuclear gaze palsy and early falls, referred to as Richardson's syndrome (PSP-RS). Other presentations include postural instability (PSP-PI), Parkinsonism (PSP-P), speech/language disorder (PSP-SL), frontal presentation (PSP-F), ocular motor dysfunction (PSP-OM), and corticobasal syndrome (PSP-CBS). However, differences across the early presentations and their subsequent clinical courses remain to be elucidated.

Objective

This study aimed to characterize early PSP subtypes and their subsequent progressions using a large postmortem dataset.

Methods

An automated pipeline incorporating fine-tuned Chat Generative Pretrained Transformer (ChatGPT) was developed. The pipeline collecte

SUBMITTER: Ono D 

PROVIDER: S-EPMC12534292 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature