Evaluating the use of rodents as in vitro, in vivo and ex vivo experimental models for the assessment of tyrosine kinase inhibitor-induced cardiotoxicity: a systematic review.

ABSTRACT: Tyrosine kinase inhibitors (TKIs) are widely used in cancer therapy yet are strongly associated with acute and chronic cardiotoxicity in patients. There is a critical need to advance our understanding of the pathophysiology that underlies TKI-mediated cardiotoxicity, and central to this is the use of reproducible and relevant preclinical models, which are employed in the evaluation of TKIs across the drug discovery pipeline. We have conducted a systematic review of the literature to determine how rodent models are used in the measurement of TKI-induced cardiotoxicity, focusing on animal reports, physiological cardiac outputs, histopathology, and biomarkers. A PRISMA-compliant systematic review was conducted using PubMed, Scopus, and Web of Science to identify studies reporting on TKI-induc

SUBMITTER: Gill L 

PROVIDER: S-EPMC12534346 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature