Comorbidity and medication patterns in atrial fibrillation patients: association with adverse clinical outcomes.

ABSTRACT: Managing atrial fibrillation (AF) patients with multiple comorbidities and complex medications is challenging. This study aimed to identify different patient profiles of AF based on comorbidities and medicines combinations and to explore their associations with the risk of adverse outcomes. This cohort study included patients with AF from the anticoagulant outpatient clinic at a hospital in Italy, undergoing follow-ups every 6 months. Comorbidity and medication patterns were identified using latent class analysis. Cox regression was used to explore associations with thromboembolism, major bleeding, falls, and death-separately and composite. A total of 633 patients with AF (mean age 80.5 ± 6.9 years, 52.5% women) treated with direct oral anticoagulants were followed for a median of 24.2 (IQ

SUBMITTER: Celik D 

PROVIDER: S-EPMC12534355 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature