Intraperitoneal Perfusion with Cisplatin or Mitomycin C Improves Survival in Mice Bearing Peritoneal Metastases from Ovarian Cancer.

ABSTRACT:

Background

Hyperthermic intraperitoneal chemotherapy (HIPEC) following cytoreductive surgery is a potentially curative treatment for patients with peritoneal metastases. Currently, there is no standardized protocol for performing HIPEC and there is large variation in the key parameters. In vivo models can be a valuable tool to better understand the impact of these parameters and how to improve this treatment strategy.

Methods

Peritoneal tumors were established in immunodeficient mice by intraperitoneal injection of the high-grade serous human ovarian cancer cell line B76. Thirty-minute perfusion with cisplatin or mitomycin C at 37 or 41 °C was performed 4 days later. Treatment efficacy was assessed by measuring bioluminescence and overall survival.

Results

We successf

SUBMITTER: Andersson Y 

PROVIDER: S-EPMC12534361 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature