Immunomodulatory effects of the herbicide glyphosate following occupational exposure.

ABSTRACT: Glyphosate, a widely used herbicide, has raised concerns regarding its impact on human health and the environment due to its widespread and excessive use. Adverse effects on the immune system have been reported. In this study, 26 vineyard workers in Veneto vineyards were examined before and after glyphosate applications to investigate possible immune parameter changes. Glyphosate exposure led to alterations in plasma cytokine levels, including marked increases in IL-4 and IL-5, a modest rise in IFN-γ, and a decrease in IL-8. No changes in plasma IL-12/23p40, IL17 and IL-33 were found. The IFN-γ/IL-4 ratio decreased, accompanied by changes in T cell subpopulations. Notably, a decrease in the T helper 1/T helper 2 cell ratio, attributed to reduced Th1 cells and increased Th2 cells, was obser

SUBMITTER: Maddalon A 

PROVIDER: S-EPMC12534365 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature