Blastocyst quality and congenital malformation risk in singleton births after frozen embryo transfer.

ABSTRACT: The relationship between blastocyst morphological quality and the risk of congenital malformations in assisted reproductive technology (ART) remains poorly understood, limiting clinical decision-making for embryo selection. We conducted a retrospective cohort study of 3986 frozen embryo transfer cycles (January 2014-June 2023) to evaluate whether blastocyst morphological quality influences the risk of congenital malformations. Blastocysts were classified according to Gardner's grading system, and 1:2 propensity score matching was applied to control for maternal age, BMI, infertility characteristics, and other potential confounders. After matching, 1743 singleton births were analyzed (1162 good-quality vs. 581 poor-quality blastocysts). Baseline characteristics were well balanced between gr

SUBMITTER: Du L 

PROVIDER: S-EPMC12534368 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature