Viral oncogenes drive biphenotypic lymphoproliferative malignancy in transgenic mice.

ABSTRACT: Human T-cell leukemia virus type 1 (HTLV-1) is the cause of adult T-cell leukemia/lymphoma (ATLL) and viral oncogenic proteins, Tax and Hbz, are critical drivers of malignancy. Expression of both CD2 and CD20 has been described in a subset of ATLL cases. Transgenic mice were engineered to monitor lymphoma and leukemia after expression of Hbz and doxycycline-inducible Tax in activated T cells under the regulation of the human granzyme B (GZMB) promoter. These mice spontaneously developed lymphoproliferative disease characterized by the expansion and transformation of Cd2 + Cd20 + cells resulting in lymphoma and / or leukemia with involvement of spleen, liver, and lymph nodes. Single cell and bulk RNAseq analyses were used to characterize differences in gene expression in the Cd2 + Cd20 + ce

SUBMITTER: Rauch DA 

PROVIDER: S-EPMC12534375 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature