Targeted proteomics analysis in type 1 diabetes identifies lower agouti-related protein levels in individuals with impaired hypoglycaemia awareness.

ABSTRACT: Impaired awareness of hypoglycaemia (IAH) is a complication of diabetes treatment, whereby individuals are no longer able to feel an oncoming hypoglycaemic event. IAH may be a result of central nervous system adaptation to low recurrent hypoglycaemias, however the precise pathways involved remain unknown. This study employed proteomics analysis to explore potential pathophysiological pathways in IAH, using a nested case-control design within the Dutch Type 1 Diabetes Biomarker study. The Olink^® Cardiovascular II panel was used for targeted proteomics, comparing 67 individuals with IAH to 108 age- and sex-matched individuals with normal awareness of hypoglycaemia (NAH). Univariate analysis revealed that agouti-related protein (AGRP) levels were significantly lower in individuals

SUBMITTER: Varkevisser RDM 

PROVIDER: S-EPMC12534408 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature