NR4A1 expression aberrations contribute to radiotherapy resistance in gastric cancer.

ABSTRACT: Gastric cancer (GC) is a common and life-threatening malignancy. It is often diagnosed at advanced stages. A major challenge in treatment is the development of radiotherapy resistance. This resistance significantly reduces the effectiveness of therapy. Therefore, our objective is to pinpoint genes linked to the resistance against radiotherapy in gastric cancer. The NR4A1 expression exhibited abnormalities in radioresistant gastric cancer cells, specifically MKN45-R and AGS-R cells, in comparison to their respective parental cells. Through high-throughput sequencing, we screened these cells and utilized quantitative reverse transcription-polymerase chain reaction analysis (qRT-PCR) to quantify NR4A1 expression. Functional analyses of NR4A1 in GC radioresistance were conducted by overexpress

SUBMITTER: Ni P 

PROVIDER: S-EPMC12534420 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature