KLF2 may suppress chicken adipogenesis by enhancing the GATA2 transcription.

ABSTRACT: Kruppel-like factor 2 (KLF2) acts as an essential modulator of adipogenesis; nevertheless, the exact molecular pathways governing its role remain uncharacterized. This investigation characterized the expression profile of KLF2 in human adipose tissue and elucidated the mechanisms by which KLF2 modulates adipogenesis in avian models. The KLF2 mRNA expression in human adipose tissues was substantial and exhibited significant heterogeneity influenced by gender and anatomical location, suggesting that KLF2 regulated adipose tissue functionality. In chicken preadipocytes ICP1, the KLF2 protein increased at the first 24 h of oleate-induced adipogenic differentiation and subsequently decreased over time. KLF2 facilitated the cellular proliferation of ICP1 cells (P < 0.05). Moreover, KLF2 overexpr

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12534465 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature