Overexpression of LINC01354 predicts well prognosis and suppresses esophageal cancer progression.

ABSTRACT: Long non-coding RNA (lncRNA) LINC01354 is involved in the progression of some cancer types, but the expression profile and prognostic value of this lncRNA in most tumor types, as well as its role and mechanism in esophageal cancer (ESCA), remain poorly characterized. Here, we identify LINC01354 as a tumor-suppressive lncRNA that inhibits ESCA progression by disrupting cell division signaling. Clinically, a pan-cancer analysis revealed widespread downregulation of LINC01354 in tumors compared to normal specimens, including ESCA and breast cancer (BRCA). Low tumor LINC01354 expression correlated with poor overall survival (OS) in ESCA and BRCA patients. In addition, the low expression of LINC01354 in tumors was validated again by two ESCA cohorts, and LINC01354 showed promising diagnostic po

SUBMITTER: Cui Y 

PROVIDER: S-EPMC12534473 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature