Impaired antibody responses to heterologous ChAdOx1 nCoV-19 and BNT162b2 vaccination in individuals with type 2 diabetes.

ABSTRACT: The COVID-19 pandemic has caused many deaths worldwide, especially in patients with type 2 diabetes mellitus (DM). Owing to the association of type 2 DM with immune dysfunction, we evaluated the impact of DM on the humoral immune responses induced by inactivated (Sinovac, SV), viral vector (ChAdOx1 nCoV-19, Az) and mRNA (BNT162b2, BNT) vaccines, compared with those in non-DM individuals. The levels of anti-spike (S) and neutralizing antibodies (nAbs) against the S1 domain/receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) before and after COVID-19 vaccination were determined. The immune response in non-DM individuals heterologously immunized with the Az-BNT regimen was more robust than that in those immunized with other regimens. Notably, individu

SUBMITTER: Saenwongsa W 

PROVIDER: S-EPMC12534484 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature