Regularized CCA identifies sex-specific brain-behavior associations in adolescent psychopathology.

ABSTRACT: Adolescence is a critical period of neural development and a sensitive window for the emergence of psychiatric symptoms. Resting-state functional MRI (rs-fMRI) provides a unique opportunity to investigate brain-behavior associations. However, the role of sex-specific differences in these associations remains underexplored, despite their potential to reveal heterogeneous neurobiological mechanisms and guide personalized interventions. In this study, we analyzed data from the Adolescent Brain Cognitive Development (ABCD) Study, comprising 7,892 adolescents (9-10 years old, 3,896 females). Using Canonical Correlation Analysis (CCA) and a rigorous cross-validation framework, we identified associations between cortical-to-cortical (Cor-Cor) and cortical-to-subcortical (Cor-Sub) functional conne

SUBMITTER: Milecki L 

PROVIDER: S-EPMC12534495 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature