Unraveling the brain expression of bdnf in a mouse model of anorexia nervosa.

ABSTRACT: Anorexia nervosa (AN) is a complex psychiatric disorder characterized by severe caloric restriction and distorted body image, leading to significant psychological and physiological complications. Brain-derived neurotrophic factor (BDNF) plays a critical role in cognitive function and metabolic regulation. A mutation in the BDNF gene is associated with anorexia nervosa. This study examines the effects of food restriction, refeeding and short-term refeeding on the expression of Bdnf and its receptor (tropomyosin receptor kinase B TrkB/Ntrk2) in key brain regions involved in reward and cognitive function. We assessed BDNF mRNA levels in the dorsal striatum (DS), nucleus accumbens, ventral tegmental area, and prefrontal cortex (PFC) of AN-like mice subjected to different feeding regimes combin

SUBMITTER: Cao J 

PROVIDER: S-EPMC12534498 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature