Bioinformatics analysis of IFI6 as a novel prognostic biomarker and its correlation with immune infiltration in breast cancer.

ABSTRACT: The aim of this study was to identify biomarkers associated with breast cancer prognosis and to explore the underlying pathogenic mechanisms. Interferon alpha-inducible protein 6 (IFI6), known as a proliferative and anti-apoptotic factor, has been implicated in various malignant diseases. However, its biological roles in breast cancer remain poorly understood. To address this, we employed bioinformatics analyses to investigate the expression and prognostic significance of IFI6 in breast cancer. Our findings revealed that IFI6 was upregulated in breast cancer and was associated with histological subtypes and lymph node metastasis status. Kaplan-Meier plotter analysis demonstrated that high IFI6 expression correlated with poor prognosis in breast cancer patients with ER-positive, PR-positive

SUBMITTER: Jiang L 

PROVIDER: S-EPMC12534504 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature