PH-triggered liposomal strategy for cisplatin in lung cancer therapy.

ABSTRACT: Cisplatin (Cis) is the first-line chemotherapy for treating the non-small-cell lung cancer. However, its low solubility, low bioavailability, and potential side effects limit its use. To overcome these drawbacks, novel pH-sensitive liposomal Cis formulations have been developed using a rapid and practical ethanol injection technique. In this study, two different liposome types were prepared, one based on phosphatidylcholine and cholesteryl hemisuccinate (CHEMS), the other containing 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) in combination with CHEMS. Their homogeneity, smaller particle sizes (< 200 nm) and drug integration were confirmed using the DLS method and FT-IR and SEM-EDS, respectively. The loading efficiency was changed from 35 to 50% depending on the composition. In vi

SUBMITTER: Demirbolat GM 

PROVIDER: S-EPMC12534553 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature