A Role for High Mobility Group Box 1 (HMGB1) Release in the Pathogenesis of Gastroesophageal Reflux Disease.

ABSTRACT:

Background

Many gastroesophageal reflux disease (GORD) patients have heartburn symptoms despite PPI treatment, potentially via esophageal mucosa exposure to weakly acidic bile salts, leading to oxidative stress. High mobility group box 1 (HMGB1) is a nuclear protein secreted during oxidative stress that binds to receptors including TLR2, TLR4, and RAGE, inducing inflammatory signaling. We describe the release and potential downstream effects of HMGB1 in GORD.

Methods

Esophageal biopsies were obtained from healthy controls (HC), functional heartburn (FH), non-erosive reflux disease (NERD), and erosive reflux disease (ERD) patients. Biopsies were analyzed by RNA-sequencing, and the expression of TLR2, TLR4, and RAGE was assessed with immunohistochemistry. NE-1 cells were chall

SUBMITTER: Leech T 

PROVIDER: S-EPMC12534581 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature