Metabolic impact of dietary glycine supplementation in individuals with severe obesity.

ABSTRACT: Glycine plays a central role in human metabolism, and an adequate supply is required for synthesizing glutathione (GSH), eliminating excess metabolites as acylglycine via the glycine conjugation detoxification pathway, and maintaining 1-carbon cycle activity. However, glycine is deficient in individuals with severe obesity, which may compromise these pathways and metabolic health. This exploratory study examines whether dietary glycine supplementation could correct glycine deficiency and impairments in glycine-dependent metabolic pathways. 19 participants with severe obesity (BMI 38.3 ± 5.3 kg/m²) were treated with dietary glycine (100 mg/kg/day) for two weeks. We found that treatment significantly increased the plasma concentration of glycine and enhanced the urinary excretion

SUBMITTER: Tan HC 

PROVIDER: S-EPMC12534614 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature