The impact of musical intervention during fetal and infant stages on social behavior and neurodevelopment in mice.

ABSTRACT: The potential benefits of music in prenatal and early childhood education are widely acknowledged, yet the neurobiological mechanisms underlying its effects on social behavior, particularly during early development, remain underexplored. This study investigated the impact of musical intervention on social behavior and neurodevelopment in mice, focusing on mechanisms at various developmental stages. Pregnant mice were exposed to music starting at embryonic day 13 (E13) and continuing until postnatal weeks 1, 3, or 5. Behavioral tests, including three-chamber social task and social interaction assays, revealed that musical exposure significantly enhanced social interaction in adult mice. mRNA sequencing revealed notable changes in the expression of genes associated with social behavior in bo

SUBMITTER: Qiu R 

PROVIDER: S-EPMC12534615 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature