Gut microbiota and risk of cervical cancer: a Mendelian multivariable randomization study.

ABSTRACT:

Background and hypothesis

Epidemiological evidence demonstrates associations between gut microbial dysbiosis and cervical cancer, though causal inference remains limited by potential confounding.

Study design

A meta-analysis of the largest available genome-wide association study (GWAS) meta-analysis using the MiBioGen consortium (n = 14,306 individuals; 8,107,040 SNPs analyzed) was conducted for the summary statistics of the gut microbiome. A two-sample Mendelian randomization study was performed using the statistics of cervical cancer from BioBank Japan (BBJ) and the European Bioinformatics Institute (EBI) GWAS Catalog. The causal relationship between the gut microbiome and cervical cancer was examined using inverse variance weighting, maximum likelihood, MR-Egger, weighted

SUBMITTER: Lu L 

PROVIDER: S-EPMC12534617 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature