RNA adenosine modification writers define characteristics of immunity and prognosis in head and neck squamous cell carcinoma.

ABSTRACT:

Purpose

To identify potential roles of RNA modification patterns in immunotherapy and prognosis in head and neck squamous cell carcinoma (HNSCC).

Methods

We performed a multiomics analysis of 26 "writers" from four major adenine RNA modifications in 866 HNSCC samples from 3 datasets. We identified two distinct RNA modification patterns using unsupervised clustering of 13 RNA modification writers related to prognosis, and compared biological characteristics like immune cell infiltration, stemness, TME and patient prognosis between patterns. The RNA modification score (RMscore) model was constructed to quantify the RNA modification-related subtypes of individual tumors.

Results

The RMcluster A had a longer median overall survival (OS) than RMcluster B (5.40 vs. 3.82 yea

SUBMITTER: Wang R 

PROVIDER: S-EPMC12534622 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature