The effects of genetically determined plasma methyltransferases on digestive system cancers: a comprehensive bidirectional two-sample Mendelian randomization analysis.

ABSTRACT:

Objectives

The causal relationship between plasma methyltransferase protein concentrations and the onset of digestive system cancers remains unclear. This study employed a Mendelian randomization (MR) analysis to explore potential causal relationships.

Methods

A bidirectional two-sample MR analysis was conducted to systematically investigate causal associations. Data from the FinnGen Biobank and the European Bioinformatics Institute (EBI) were used for verification. This analysis focused on 14 types of methyltransferases and 5 types of digestive system cancers.

Results

The analysis identified specific methyltransferases associated with increased risks for certain digestive system malignancies. Notably, dual verification confirmed that HEMK2 is associated with an incre

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12534628 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature