Efficacy and safety of endoscopic glue injection in acute peptic ulcer bleeding.

ABSTRACT:

Background

Optimal management of peptic ulcer bleeding remains a clinical challenge.

Objectives

To evaluate the efficacy and safety of endoscopic glue injection (EGI) for acute peptic ulcer bleeding.

Design

Single-center retrospective study.

Methods

This study (October 2015-December 2024) included adults (⩾18 years) with high-risk peptic ulcer bleeding (Forrest Ia-IIa) treated with EGI using n-butyl α-cyanoacrylate ester or standard endoscopic treatment (SET) involving contact thermal therapy and hemoclips. The primary endpoint was the rebleeding within 7 days, and the secondary endpoints included rebleeding within 30 days, 30-day all-cause mortality rate, occurrence of adverse events (AEs), and length of hospital stay and intensive care unit (ICU) stay. Risk f

SUBMITTER: Qi X 

PROVIDER: S-EPMC12534813 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature