High Myopia-Induced Optic Nerve Head Deformation and Glaucoma Progression: A Three-Year Follow-Up Study.

ABSTRACT:

Purpose

To investigate the biomechanical effects of high myopia (HM)-related optic nerve head (ONH) structural changes on glaucoma progression and identify key predictive parameters.

Methods

This prospective cohort study enrolled 242 eyes: 97 highly myopic glaucoma (HMG), axial length > 26.5 mm; 145 open-angle glaucoma (OAG), axial length ≤ 26.5 mm. ONH parameters, including Bruch's membrane opening (BMO), anterior scleral canal opening (ASCO) areas, neural canal minimum cross-sectional area (NCMCA), and ASCO-BMO offset, were quantified via spectral-domain OCT. Visual field (VF) defects and parapapillary retinal nerve fiber layer (pRNFL) thickness were monitored over 3 years. Generalized linear mixed models and multivariate regression were used for analysis.

Results

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SUBMITTER: Dai J 

PROVIDER: S-EPMC12534888 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature