Maresin 1 Ameliorates Blue Light Overexposure-Induced Meibomian Gland Dysfunction via Inhibition of NLRP3/Caspase-1/GSDMD-Mediated Pyroptosis.

ABSTRACT:

Purpose

Blue light emitted from digital screens represents a significant environmental factor contributing to computer vision syndrome-related ocular surface damage. This study aimed to investigate the protective effects of maresin 1 (MaR1), a specialized proresolving lipid mediator derived from docosahexaenoic acid, in meibomian gland dysfunction (MGD) induced by blue light overexposure in both in vivo and in vitro experiments.

Methods

In vivo, male Sprague-Dawley rats were exposed to blue light for 1 month to induce MGD. After 14 days of MaR1 or PBS eye drop treatment, corneal fluorescein staining and inflammatory cytokine expression were evaluated. Lipid secretion and ductal keratinization were assessed using Nile red and keratin 1 staining. In vitro, pyroptosis was induc

SUBMITTER: Wu M 

PROVIDER: S-EPMC12534890 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature