Long-Term Corneal Reshaping Using Riboflavin-UVA Crosslinking Combined With Decorin in Rabbits.

ABSTRACT:

Purpose

To establish a preclinical proof of concept for a novel, non-ablative method for long-term corneal reshaping and to investigate its biomechanical and safety profiles.

Methods

A rabbit model of non-ablative corneal reshaping was established using a custom molding device. The optimal protocol involved stromal reshaping stabilized by riboflavin-ultraviolet A (UVA) collagen cross-linking (CXL; 7.2 J/cm2), with topical decorin applied as a biological modulator to maintain corneal clarity. Corneal topography was monitored for 12 months. Safety was assessed via in vivo clinical examinations, histology, and electron microscopy. Biomechanical properties were evaluated ex vivo via uniaxial tensile testing of rabbit corneas and human corneal lenticules.

Results

In vivo,

SUBMITTER: Feng C 

PROVIDER: S-EPMC12534892 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature