Measuring Rod- and Cone-Photoreceptor-Specific Vision in Inherited Retinal Diseases Using a Commercial Perimeter.

ABSTRACT:

Purpose

The primary pathology in most inherited retinal diseases (IRDs) is located within photoreceptors. Standard automatic perimetry (SAP) can measure photoreceptor disease severity but cannot distinguish between rods, long/middle-wavelength (L/M)-sensitive, and short-wavelength (S)-sensitive cones. Herein we developed a protocol that can provide photoreceptor-specific sensitivities.

Methods

A commercial (unmodified) perimeter was used to develop a clinical protocol that includes five profiles along the vertical meridian, utilizing different chromatic stimuli presented in the dark-adapted state or on adapting backgrounds. Data were recorded by the Perimetry for IRD (PERIRD) consortium in control participants and patients with IRDs.

Results

The protocol was developed

SUBMITTER: Wu V 

PROVIDER: S-EPMC12534894 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature