Optimizing endectocide and ectocide compound evaluation in Anopheles malaria vectors.

ABSTRACT:

Background

Mass endectocide or ectocide treatment of humans or livestock has been suggested as a possible malaria vector control tool. This work provides guidance for in vitro endectocide and ectocide experiments and raises biological points for further evaluation.

Methods

Three experiments with ivermectin were performed with Anopheles dirus and Anopheles minimus. The first experiment assessed the impact of a sugar diet (10% sucrose, "Sucrose"; multivitamin syrup, "Multivitamin"; or multivitamin syrup followed by 10% sucrose, "Mix") on mosquito mortality following ingestion of a range of ivermectin-spiked blood meal concentrations. The lethal concentrations that kill 50% (LC₅₀) and 90% (LC₉₀) of mosquitoes were estimated using a normalized concentration

SUBMITTER: Kobylinski KC 

PROVIDER: S-EPMC12534914 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature