Antimicrobial activity and possible mechanisms of juglone against Escherichia coli, Staphylococcus aureus, and Salmonella pullorum.

ABSTRACT:

Background

Escherichia coli, Staphylococcus aureus, and Salmonella pullorum are significant pathogens that threaten livestock and poultry health. Although antibiotics and synthetic antimicrobial agents can combat these pathogens, antibiotic resistance remains a major concern. Recent decades have seen growing interest in antibiotic alternatives. Juglone, a natural naphthoquinone compound from Juglandaceae plant, exhibits strong antimicrobial activity against S. aureus. However, its antimicrobial mechanism is not yet fully understood. This study investigated the antimicrobial mechanism of juglone from the perspectives of cell biology, cell morphology, and transcriptomics.

Results

Juglone had potent antimicrobial effects against E. coli, S. aureus, and S. pullorum. The minimum

SUBMITTER: Wang L 

PROVIDER: S-EPMC12534947 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature