Lactobacillus rhamnosus B16 regulates lipid metabolism homeostasis by producing acetic acid.

ABSTRACT:

Background

Hyperlipidemia, a chronic disorder caused by abnormal lipid metabolism, increases risks of atherosclerosis and cardiovascular diseases. Current single-target drugs have limited efficacy and side effects, prompting interest in probiotics such as Lactobacillus rhamnosus, though their mechanisms remain unclear.

Methods

A novel Lactobacillus rhamnosus strain from healthy human feces was identified via API 50CH and ANI analysis. Integrated genomic and proteomic analyses were performed on the novel Lactobacillus rhamnosus B16 (L. rB16) strain to characterize its lipid metabolism-related traits. A cholesterol degradation assay, gastrointestinal fluid tolerance test, and biofilm formation assay were used to evaluate the functional properties of L. rB16, while foam cell mo

SUBMITTER: Che Z 

PROVIDER: S-EPMC12534967 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature