Orchestration of hepatocyte inflammatory responses by monocytes during acute viral hepatitis in ducks in vitro.

ABSTRACT: Severe liver inflammation, in which the interaction between circulating immune cells and hepatocytes plays a crucial role, is a major concern in acute viral hepatitis. Nevertheless, the mechanisms by which these circulating immune cells drive hepatocyte inflammatory responses remain inadequately understood. In this study, we demonstrate that the transcription of several notable proinflammatory cytokines, including IL-1β, IL-6, and TNF-α, is markedly greater in cocultures of duck hepatitis A virus (DHAV)-infected hepatocytes than in hepatocytes infected with only DHAV. Simultaneously, the remodelling of the mature tRNAome in infected hepatocytes is orchestrated by coculturing peripheral blood mononuclear cells (PBMCs). Consistent with the effects of PBMC coculture, monocyte coculture also e

SUBMITTER: Gong L 

PROVIDER: S-EPMC12534983 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature