Longitudinal changes in estimated glucose disposal rate and risk of cardiovascular disease among adults with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study.

ABSTRACT:

Background

The aging population and medical advancements have led to a rise in chronic conditions such as metabolic syndrome, cardiovascular disease (CVD), and chronic kidney disease, giving rise to the concept of cardiovascular-kidney-metabolic (CKM) syndrome. The estimated glucose disposal rate (eGDR) is an important surrogate marker of insulin sensitivity; however, its longitudinal impact on CVD risk across CKM syndrome stages 0 to 3 remains unclear.

Methods

Data were derived from the China Health and Retirement Longitudinal Study (CHARLS). After excluding participants lacking CKM stage 0-3 diagnostic indicators and those with incomplete data, a total of 3,503 eligible individuals were included. eGDR was calculated based on waist circumference, hypertension status, and Hb

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12534988 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature