Curcumin in prostate cancer: a systematic review of molecular mechanisms and nanoformulated therapeutic strategies.

ABSTRACT:

Background

Prostate cancer (PCa) is one of the most prevalent malignancies in men, often progressing to castration-resistant forms and resisting conventional therapies. Curcumin, a polyphenol from Curcuma longa, has emerged as a potent anti-cancer agent by modulating several molecular pathways.

Objective

This systematic review seeks to synthesize current preclinical evidence on the molecular mechanisms underlying curcumin's effects in PCa and to evaluate nanoformulation strategies developed to enhance its pharmacokinetics and therapeutic efficacy.

Methods

A comprehensive search of five major databases up to March 1, 2025 identified 22 eligible studies on curcumin and PCa. Data on molecular pathways, therapeutic outcomes, and delivery systems were extracted and assesse

SUBMITTER: Esmaeli M 

PROVIDER: S-EPMC12535016 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature