Exploring the pharmacological action mechanism of chamomile essential oil on the treatment of breast cancer based on network pharmacology.

ABSTRACT:

Background

Chamomile essential oil (CEO) can be beneficial in cancer therapy. The aim of the current research is to explore the underlying mechanism of CEO for breast cancer treatment by network pharmacology approach and evaluate its anti-breast cancer capacity in vitro.

Methods

We extracted CEO from chamomile flowers and analyzed its chemical components by using GC-MS/MS. Network pharmacology method was employed to screen the active components, potential targets and possible mechanism of CEO for breast cancer treatment. The molecular docking was used to validate the results of network pharmacology. Cell viability, apoptosis and cell cycle assay were used to assess anti-breast cancer effect of CEO.

Results

In network pharmacology analysis, we found the 12 effective co

SUBMITTER: Maitisha G 

PROVIDER: S-EPMC12535045 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature