Infection with Anaplasma phagocytophilum in a seronegative patient in Sicily, Italy: case report.

ABSTRACT:

Background

Anaplasma phagocytophilum causes human granulocytic anaplasmosis (HGA) in humans, which has been recognized as an emerging tick-borne disease in the United States and Europe. Although about 65 cases of HGA have been reported in Europe, some of them do not fulfill the criteria for confirmed HGA. Confirmation of HGA requires A. phagocytophilum isolation from blood, and/or identification of morulae in granulocytes and/or positive PCR results with subsequent sequencing of the amplicons to demonstrate specific rickettsial DNA. Seroconversion or at least fourfold increase in antibody titers to A. phagocytophilum has been used as criteria for confirmed HGA also.

Case presentation

Infection with A. phagocytophilum was confirmed by PCR in a patient in Sicily, Italy, who ha

SUBMITTER: de la Fuente J 

PROVIDER: S-EPMC1253508 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature