Development and validation of radiopathomics models for predicting molecular subtypes and WHO grades in adult-type diffuse gliomas: a multicenter study.

ABSTRACT:

Background

Early identification of molecular subtypes and WHO grades in adult-type diffuse gliomas (ADGs) provides critical evidence for prognostic evaluation and personalized therapeutic decision-making. This study aims to develop and validate radiopathomics models for the prediction of molecular subtypes and WHO grades in ADGs, addressing the limitations of unimodal approaches.

Methods

In this retrospective multicenter study, 499 consecutive ADG patients from three centers (training set: n = 306, testing set: n = 132, external validation set: n = 61) were included. Radiomics features were extracted from preoperative MRI sequences (T2-FLAIR and CE-T1WI), while pathomics features were derived from whole-slide images (WSIs). Feature selection methods and Multilayer Perceptron

SUBMITTER: Liang Q 

PROVIDER: S-EPMC12535137 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature