Impact of thyroid dysfunction on clinical outcome in head and neck cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

The influence of thyroid dysfunction on the clinical outcomes of head and neck cancer (HNC) patients remains an area of ongoing investigation, with previous studies yielding variable results. Treatments for HNC, particularly radiotherapy, frequently impact thyroid function. This meta-analysis aimed to synthesize the available evidence on the association between thyroid status (dysfunction vs. euthyroid) and survival outcomes in HNC patients.

Methods

A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Medline, Web of Science, Cochrane Library, Embase and Scopus were searched (January 2000-October 2024) for studies comparing survival outcomes (primarily Overall Sur

SUBMITTER: N C S 

PROVIDER: S-EPMC12535142 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature