Utilizing resting motor threshold to predict cognitive function in drug-naive patients with major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a common and disabling condition associated with significant cognitive impairments that persist over the long term, affecting patients' social function. Traditional cognitive testing methods are time-consuming and subjective. This study investigates whether resting motor threshold (RMT), a neurophysiological measure of motor cortical excitability, can predict cognitive function in drug-naive patients with MDD, with a focus on sex-specific differences.

Methods

This cross-sectional study enrolled 158 first-episode, drug-naive patients with MDD from August 2023 to April 2024. Participants underwent comprehensive cognitive assessments using the MATRICS Consensus Cognitive Battery (MCCB) and transcranial magnetic stimulation (TMS) to

SUBMITTER: Xu L 

PROVIDER: S-EPMC12535144 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature