A novel imagery-based retrieval-extinction training for intervention in nicotine addiction.

ABSTRACT:

Background

Retrieval-extinction training based on the theory of memory reconsolidation has promising intervention effects for addiction. However, the conventional conditioned stimuli used in retrieval-extinction training have limitations in lack of contextual and selective activation of memories, which limits intervention efficacy and clinical translation. Therefore, we developed a novel imagery-based retrieval-extinction training (I-RE) and examined its effects on nicotine addiction.

Methods

This study included 57 nicotine-dependent individuals randomly assigned to either the experimental (n = 29) or control (n = 28) group. Participants were exposed to a 5-min imagery script cue, followed by a 10-min rest period and 60-min extinction training session. Short- and long-term (

SUBMITTER: Chen B 

PROVIDER: S-EPMC12535158 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature