Caloric Restriction Enhances the Efficacy of Antiandrogen Therapy in Prostate Cancer by Inhibiting Androgen Receptor Translation.

ABSTRACT: Epidemiologic studies suggest that diet can affect the incidence, progression, and response to treatment in multiple cancers, including prostate cancer. In this study, we investigated the use of dietary interventions, specifically caloric or protein restriction, in combination with antiandrogen therapy as a treatment for prostate cancer. Caloric restriction through alternate-day fasting (ADF) reduced androgen receptor (AR) expression and signaling. This reduction in AR enhanced the antitumor activity of the AR antagonist enzalutamide in multiple mouse models of prostate cancer. Mechanistic studies revealed that nutrient starvation via ADF predominantly decreased AR mRNA translation at the elongation stage due to AA limitation. Pharmacologic agents that similarly impair translation elongati

SUBMITTER: Cordova RA 

PROVIDER: S-EPMC12535181 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature