Prevalence and Associated Factors of Chronic Depression Among Older Adults: A Systematic Review, Meta-Analysis, and Meta-Regression.

ABSTRACT:

Objectives

Although late-life depression is common, there has previously not been a comprehensive review of chronic depression (CD) in older adults. This systematic review summarizes prevalence rates, potential risk factors, and consequences of CD in later life.

Methods

This preregistered review (PROSPERO: CRD42025649324) searched MEDLINE, Web of Science, CINAHL and PsycINFO from inception to February 2025. Observational studies reporting the prevalence of CD in older adults (mean age 60+) were included. Study quality was assessed using the Joanna Briggs Institutes Critical Appraisal Tool. Random-effects models were used to estimate pooled prevalence across subgroups and meta-regression analyses were used to explore sources of heterogeneity.

Results

A total of 39 arti

SUBMITTER: Stratmann MW 

PROVIDER: S-EPMC12535281 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature