PRDM13 is required for specification of PAX2 lineage inhibitory neurons in the developing cerebellum.

ABSTRACT: Shared genetic developmental programs in which specific transcription factors affect similar cell fate decisions in distinct tissues are common. In the developing dorsal neural tube and cerebellum, PTF1A is essential for specification of GABAergic inhibitory neurons and suppression of alternative glutamatergic excitatory neuronal fates. Previous studies in the mouse dorsal neural tube identified the transcriptional repressor PRDM13 as a transcriptional target of PTF1A that functions to suppress the alternate cell fates to ensure precision in neuronal cell identity. The presence of PRDM13 in PTF1A + cerebellar progenitors suggests a similar role for PRDM13 in cerebellar neuronal specification. Cerebellar agenesis in humans with missense mutations in PRDM13, and perturbations in cerebellar d

SUBMITTER: Ma ZZ 

PROVIDER: S-EPMC12535285 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature