Sustained, Reversible, and Adaptive Non-Equilibrium Steady States of a Dissipative DNA-Based System.

ABSTRACT: Inspired by nature, researchers have developed several chemical fuel-driven supramolecular systems aimed at achieving improved kinetic control over their formation and functions. Alongside, DNA-based systems regulated by energy-dissipating mechanisms have been reported. However, the majority of these systems rely on batchwise additions of chemical fuels to closed reactors, resulting in transient non-equilibrium states that differ fundamentally from the sustained and highly adaptable non-equilibrium steady states (NESS) maintained by living systems through continuous energy dissipation. Here, we demonstrate sustained NESS of a dissipative DNA strand-displacement reaction achieved through the continuous supply of an RNA fuel to an open semi-batch reactor, using a custom automated setup that

SUBMITTER: Nicholas JD 

PROVIDER: S-EPMC12535392 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature