Delay-induced stochastic oscillations in gene regulation.

ABSTRACT: The small number of reactant molecules involved in gene regulation can lead to significant fluctuations in intracellular mRNA and protein concentrations, and there have been numerous recent studies devoted to the consequences of such noise at the regulatory level. Theoretical and computational work on stochastic gene expression has tended to focus on instantaneous transcriptional and translational events, whereas the role of realistic delay times in these stochastic processes has received little attention. Here, we explore the combined effects of time delay and intrinsic noise on gene regulation. Beginning with a set of biochemical reactions, some of which are delayed, we deduce a truncated master equation for the reactive system and derive an analytical expression for the correlation func

SUBMITTER: Bratsun D 

PROVIDER: S-EPMC1253555 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature