Emoface: AI-assisted diagnostic model for differentiating major depressive disorder and bipolar disorder via facial biomarkers.

ABSTRACT: Affective disorders, including Major Depressive Disorder (MDD) and Bipolar Disorder (BD), exhibit significant mood abnormalities, making rapid diagnosis essential for social stability and healthcare efficiency. Traditional diagnostic solutions, including medical history collection and psychological assessments, often struggle to differentiate their similar clinical presentations, leading to time-consuming, laborious, and a high rate of misdiagnosis. Here, we propose Emoface, an AI-assisted diagnostic model that reads the emotional activities of faces in affective disorders. By analyzing videos from 353 participants exposed to various emotional stimuli, Emoface identified unique facial digital biomarkers distinguishing BD from MDD. Based on this, Emoface contributed to develop the first dig

SUBMITTER: Yu J 

PROVIDER: S-EPMC12535589 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature