Pattern-dependent, simultaneous plasticity differentially transforms the input-output relationship of a feedforward circuit.

ABSTRACT: Memories are believed to be encoded by changes in the synaptic connections between neurons. Although many forms of synaptic plasticity have been identified, it remains unknown how such changes affect local circuits. Feedforward inhibitory networks are a common type of local circuitry and occur when principal neurons and their afferent inhibitory interneurons receive the same input. Using slices of cerebellar cortex, we explored how synaptic plasticity at multiple sites within a feedforward inhibitory network consisting of parallel fibers, interneurons, and Purkinje neurons alters the output of this circuit. We found that stimuli resembling baseline activity potentiated feedforward excitatory and simultaneously depressed feedforward inhibitory pathways. In contrast, stimuli resembling senso

SUBMITTER: Smith SL 

PROVIDER: S-EPMC1253560 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature