Research Progress of RAD51AP1 in Malignant Tumors of the Female Reproductive System.

ABSTRACT: Genomic instability may contribute to the occurrence and progression of malignant tumors of the female reproductive system. Homologous recombination repair (HRR) is vital in maintaining cellular genomic stability. RAD51-associated protein 1 (RAD51AP1) plays a vital role in HRR, mainly participating in the formation of displacement loop (D-loop), and is an important molecule for maintaining cellular genomic stability. Recent studies showed that RAD51AP1 was significantly overexpressed in a variety of cancer types and correlated with prognosis, suggesting that it may have a significant pro-carcinogenic effect. However, the mechanism underlying its pro-carcinogenic effect remains unclear, which may be closely associated with cancer stemness. Meanwhile, RAD51AP1 also plays an important role in

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12535699 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature